Systemic inflammation as a factor mediating the relationship between abdominal obesity and chronic pain syndrome in elderly patients
ORIGINAL PAPERS
Abstract
Introduction. Abdominal obesity (AO) triggers a chronic pro-inflammatory condition that serves as a single pathogenetic link between metabolic syndrome and persistent pain. In this regard, the development of a complex of laboratory markers for an objective assessment of the inflammatory status is of particular relevance. The aim is to study the mechanisms mediating the association of AO and chronic pain syndrome (CPS) in elderly patients with AO. Materials and methods. In a single-stage cohort study, the severity of inflamaging in elderly patients with abdominal obesity (AO) was assessed depending on the presence of CPS. The study included 124 patients (mean age 66.9±3.5 years). The main group (n=94) consisted of patients with AO, divided into two subgroups: group 1 (AO without CPS) — 40 people (18 men, 22 women) and group 2 (AO + CPS) — 54 people (28 men, 26 women). The control group (n=30) consisted of people without AO and CPS, who were comparable in age. The results showed that patients in the AO group had statistically significantly more pronounced metabolic disorders and manifestations of inflamaging compared with patients in the control group. The most pronounced disorders were found in elderly patients with AO+ CPS. In comparison with patients from the AO group, the HOMA-IR (Homeostasis Model Assessment of Insulin Resistance) insulin resistance index was additionally increased (+56.2%, p <0.001), the TG/HDL atherogenicity index (triglycerides/High — density lipoproteins cholesterol) (+35.3%, p <0.01), markers of inflammation — NLR (neutrophil to lymphocyte ratio) (+37.8%, p <0.01), SII (systemic immune-inflammation index) (+49.8%, p <0.001), SIRI (systemic inflammatory response index) (+44.9%, p <0.001), as well as C-reactive protein concentrations (+22.4%, p <0.01). Conclusion. The presence of CPS in elderly patients with AO is associated with a more pronounced metabolic profile disorder and increased inflamaging.
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