EFFECT OF SYSTEMIC GLUCOCORTICOSTEROIDS ON VASCULAR WALL STIFFNESS IN PATIENTS WITH ULCERATIVE COLITIS
Abstract
Introduction. Vascular wall stiffness, which is an important indicator of the cardiovascular system and reflects the ability of vessels to deform under the influence of blood pulsation, can change under the influence of inflammatory processes, especially in chronic immune-inflammatory diseases such as ulcerative colitis. Objectives and tasks. To study the effect of systemic glucocorticosteroids (GCS) on vascular wall stiffness in patients with ulcerative colitis (UC), assessed using the CAVI (Cardio-Ankle Vascular Index) index. Research methods. The work involved two groups: a control group (160 healthy individuals) and a main group (80 patients with UC lasting up to 5 years, receiving basic therapy with 5-ASA and GCS on demand). The CAVI index was measured using VaSera-VS-1000 devices. Statistical analysis was performed using the StatTech v. 4.8.0 program. Results. A significant direct correlation was found between the duration of systemic GCS therapy and the excess of the CAVI index (correlation coefficient r=0.645, p <0.001). The regression model showed that an increase in the duration of therapy by 1 month leads to an increase in the CAVI index by 0.052. A strong relationship was also found between the total dose of systemic GCS and the excess of the CAVI index (r=0.665, p <0.001), with the CAVI index increasing by 0.043 for every 1 gram of GCS. Conclusions. The data obtained demonstrates a clear dependence of vascular wall stiffness (CAVI index) on the use of systemic GCS in patients with UC.
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