University therapeutic journal

Microbiota of the nasal cavity. Part 1

REVIEWS

  • Anatoly I. Khavkin Research and Clinical Institute of Childhood, Ministry of Health of the Moscow Region; Belgorod State University
  • Dmitry A. Lukichev Novosibirsk National Research State University
  • Ekaterina E. Vergunova Novosibirsk National Research State University
  • Artem S. Tumas Novosibirsk National Research State University
  • Maria F. Novikova Novosibirsk National Research State University
  • Polina Ya. Platonova Novosibirsk National Research State University
  • Ksenia M. Stavriyani Consultative and Diagnostic Polyclinic No. 2
  • Kirill M. Nikolaychuk Novosibirsk National Research State University; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences https://orcid.org/0000-0001-8364-6066
  • Evgenia V. Shrayner Novosibirsk National Research State University; Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences; LLC "Center for New Medical Technologies"; LLC "S.LAB PHARM" ("Soloways")
  • Danil A. Sergeev Novosibirsk National Research State University
Keywords:
microbiota upper respiratory tract nasal cavity microbiota profile qualitative composition quantitative composition factors determining microbiota микробиота верхние дыхательные пути носовая полость профиль микробиоты качественный состав количественный состав определяющие микробиоту факторы

Abstract

This review analyses the qualitative and quantitative composition of the nasal cavity microbiota, the determinants of its diversification and modification under the influence of internal and external factors, and its response to therapeutic interventions and immunoprophylaxis. Key endogenous and exogenous factors influencing the microbial landscape are outlined, including genetic markers, peculiarities of upper respiratory tract anatomy, environmental conditions and socio-cultural aspects. Special attention is paid to the effects of antibiotic therapy, intranasal corticosteroids, nasal lavage techniques and surgical interventions on the microbiota composition. The significance of microbiota study for the development of innovative approaches to the prevention and treatment of respiratory tract diseases is emphasised, based on the understanding of its regulatory impact on the immune response and interspecific interactions within the microbial community.

Author Biography

Kirill M. Nikolaychuk, Novosibirsk National Research State University; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences

Junior Researcher of the laboratory of viral protease inhibitors of the Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences, first-year resident neurologist of the center for postgraduate medical education of the Institute of Medicine and Medical Technologies of the Novosibirsk State University

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How to Cite
Microbiota of the nasal cavity. Part 1: REVIEWS. (2026). University Therapeutic Journal, 7(4), 33-55. https://doi.org/10.56871/
Issue
Vol. 7 No. 4 (2025)
Section
Reviews
Published
2026-09-14

How to Cite

Microbiota of the nasal cavity. Part 1: REVIEWS. (2026). University Therapeutic Journal, 7(4), 33-55. https://doi.org/10.56871/