Патофизиологический паттерн реакции иммунной системы на вирусную инфекцию и вакцинацию при метаболическом синдроме на примере животных моделей: ПЕРЕДОВАЯ СТАТЬЯ

Людмила Михайловна  Макеева; Ксения Михайловна  Шубина; Олег Игоревич  Никитин; Наталья Вадимовна  Теплова; Павел Олегович  Богомолов; Игорь Геннадиевич  Никитин

doi:10.56871/

Pathophysiological pattern of immune system response to viral infection and vaccination in metabolic syndrome using animal models as an example

EDITORIAL

Lyudmila M. Makeeva Pirogov Russian National Research Medical University https://orcid.org/0000-0003-0755-4869
Ksenia M. Shubina Pirogov Russian National Research Medical University https://orcid.org/0000-0001-2444-8251
Oleg I. Nikitin Pirogov Russian National Research Medical University; Moscow Regional Research Clinical Institute named after M.F. Vladimirsky https://orcid.org/0000-0003-2373-4157
Natalya V. Teplova Pirogov Russian National Research Medical University https://orcid.org/0000-0003-4259-0945
Pavel O. Bogomolov Moscow Regional Research Clinical Institute named after M.F. Vladimirsky https://orcid.org/0000-0003-2346-1216
Igor G. Nikitin Pirogov Russian National Research Medical University; JSC “National Immunobiological Company” of the State Corporation “ROSTEKH” https://orcid.org/0000-0003-1699-0881

Keywords:

metabolic syndrome metabolic-associated fatty liver disease influenza acute respiratory viral infections vaccination метаболический синдром метаболически ассоциированная жировая болезнь печени грипп острые респираторные вирусные инфекции вакцинация

Abstract

The review presents data on the effect of metabolic syndrome, recreated using the example of animal models on viral infection and the effectiveness of vaccination against a number of infectious diseases. The frequency of metabolic syndrome is currently steadily increasing, leading to an increase in the incidence of acute cardiovascular events and liver pathology, up to the development of cirrhosis and hepatocellular carcinoma. After the pandemic of 2009–2011 associated with the H1N1 influenza virus, a clear, highly reliable positive relationship was revealed between the severity of the viral disease and the presence of metabolic syndrome in the patient. Understanding the mechanisms of the influence of such components of the metabolic syndrome as hyperlipidemia, insulin resistance, obesity, hypertension, and metabolically associated fatty liver disease on the development of the infectious process in the body and vaccination helps in finding new strategic solutions and their implementation in practical healthcare in terms of reducing the medical and social burden of both metabolic syndrome and infectious pathology, primarily influenza, pneumococcal infection and acute respiratory viral infections. The anomalies of the immune response to vaccination and the infectious process studied so far on the example of animal models with metabolic disorders make it possible to significantly better understand their effect on the course of viral infections and develop approaches to improve the effectiveness of vaccination.

Author Biographies

Lyudmila M. Makeeva, Pirogov Russian National Research Medical University

Assistant Professor at the Department of Hospital Therapy, Academician G.I. Storozhakov of the Institute of Clinical Medicine, member of the “Metabolic Health” working group

Ksenia M. Shubina, Pirogov Russian National Research Medical University

postgraduate student at the Department of Hospital Therapy named after Academician G.I. Storozhakov of the Institute of Clinical Medicine

Oleg I. Nikitin, Pirogov Russian National Research Medical University; Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

Assistant Professor at the Y.B. Belousov Department of Clinical Pharmacology, Institute of Clinical Medicine, Pirogov Russian National Research Medical University

Natalya V. Teplova, Pirogov Russian National Research Medical University

Head of the Y.B. Belousov Department of Clinical Pharmacology at the Institute of Clinical Medicine

Pavel O. Bogomolov, Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

Head of the Center of Hepatology, Moscow Regional Scientific Research Clinical Institute named after M.F. Vladimirsky

Igor G. Nikitin, Pirogov Russian National Research Medical University; JSC “National Immunobiological Company” of the State Corporation “ROSTEKH”

Head of the Department of Hospital Therapy named after Academician G.I. Storozhakov of the Institute of Clinical Medicine, Russian National Research Medical University named after N.I. Pirogov

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Pathophysiological pattern of immune system response to viral infection and vaccination in metabolic syndrome using animal models as an example: EDITORIAL. (2026). University Therapeutic Journal, 8(2), 7-18. https://doi.org/10.56871/

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Pathophysiological pattern of immune system response to viral infection and vaccination in metabolic syndrome using animal models as an example: EDITORIAL. (2026). University Therapeutic Journal, 8(2), 7-18. https://doi.org/10.56871/

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