Neuroand cardiotropic effects of brain derived neurotrophic factor

The combination of psychiatric and cardiological pathologies is becoming a dramatic sign for majority of patients in all countries. Depression is quite common in cardiac patients. There is a high correlation between indicators of depression and coronary heart disease, an increase in heart attacks and mortality. Comorbid depression disrupts psychosocial adaptation, complicates the treatment and rehabilitation of a somatic patient. As evidence of the association existence between depression and chronic heart failure outcomes accumulates, possible pathophysiological mechanisms underlying this association should be considered. Scientifically grounded conclusions about the key role of the brain derived neurotrophic factor (BDNF) in maintaining neuropsychiatric health and the formation of mental diseases, including depression, are supplemented by the results of studies on the participation of this neurotrophin in other physiological systems, including the cardiovascular system, in general, and the myocardium, in particular. In this paper the analysis of information on current knowledge about the basics of the molecular genetic mechanisms of BDNF regulation, his role and participation in securing functions of the nervous system and brain, as well as the cardiovascular system was carried out using the reviewing scientific data method. These new data on the possible cardioprotective effect of BDNF, including through increasing myocardial resistance to ischemic reperfusion injury, require the systematization of scientific information. The undoubted prospects for research on the role of BDNF are both the development of its mimetics, free from the shortcomings of the original molecule, and physiological, including alimentary methods of modulating the activity of cytokines and neurotrophins in organs and tissues.